小儿呼吸道疾病发病和人体生物节律之间相关性探讨

目的:探讨小儿常见呼吸道疾病发病和人体生物节律体力、情绪及智力周期的相关性。方法:收集小儿常见呼吸道疾病2 018例，计算发病日期处于其体力、情绪及智力周期的周日期、高潮期、临界期或低潮期，判定其属于哪一期发病，并进行卡方检验及圆分布分析统计学处理，据此判断小儿常见呼吸道疾病的发病与人体生物节律的体力、情绪及智力周期之间的相关性；结果:两者之间无明显相关性，且不同诊断的患儿的发病时间在生物周期上均匀分布，无集中趋势。结论:小儿常见呼吸道疾病的发病与人体生物节律之间没有明显相关性。     

Achados otorrinolaringológicos em um grupo de pacientes com doenças reumatológicas

IntroductionOtorhinolaryngological manifestations of rheumatologic diseases represent a great challenge not only to the generalistphysician but also to the ENT doctor andrheu‐ matologist. They often represent early manifestations of an autoimmune disorder which requires prompt and aggressive immunosuppressive treatment. Auditory, nasal, laryngeal and eye symptoms can be the first manifestation of rheumatic diseases and their proper assessment helps the doctor to identify signs of disease activity. The objective of this study is to identify the ENT manifestations in patients with rheumatic diseases in a high com‐ plexity hospital, regarding facilitating an early diagnosis and treatment.MethodsWe performed clinical and complete otorhinolaryngological evaluations in pa‐ tients selected from the outpatient rheumatology in a standardized manner by the use of a standardized form filling during the secondhalf of 2010.ResultsIn the study group, systemic lupus erythematosus (SLE) patients had predomi‐ nantly laryngeal manifestations, while patients with Sjögren's syndrome showed a higher prevalence of otologic manifestations. Changes in audiometric tests were found in 53% of Wegener's granulomatosis (WG) patients, 80% of relapsing polychondritis (RP), 33% of systemic lupus erythematosus (SLE) and 50% of Churg‐Strauss syndrome (SCS). Regarding nasal alterations, these were found so prevalent in all conditions, especially Churg‐Strauss syndrome.Discussion and conclusionThis study demonstrated that most patients treated in our hospi‐ tal has the ENT signs and symptoms commonly associated in previous studies on rheumat‐ ic diseases, but further studies with a larger number of patients must be made to establish such relations.     

Cutaneous necrotizing vasculitis as a manifestation of familial Mediterranean fever

Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease, which is characterized by recurrent and paroxysmal fever, peritonitis, arthritis, myalgia, and skin rashes. Although various skin lesions such as “erysipelas‐like erythema”, urticaria, nonspecific purpura, and subcutaneous nodules have been described, cutaneous vasculitis is rare. We report a Japanese case of sporadic FMF accompanied by cutaneous arteritis at the time of febrile attacks of FMF. Gene analysis revealed M694I mutation in a single allele of the MEFV gene, and oral colchicine successfully controlled both periodic fever and subcutaneous nodules of arteritis. Cutaneous necrotizing vasculitis repeatedly emerging with febrile attacks should be included among the skin manifestations of FMF.     

2011~2013年遂川县法定传染病疫情分析

目的掌握江西省遂川县法定传染病的流行特征,以制定针对性的防控措施。方法对遂川县2011~2013年网络直报的法定传染病疫情资料进行综合分析。结果遂川县2011~2013年无甲类传染病报告,共报告乙丙类传染病17种4 119例,平均发病率为253.63/10万,死亡率波动在0.19/10万~0.91/10万。全年均有发病,夏秋季传染病发病较高。10岁以下的人群,占总报告病例数的30.71%,其次是20~50岁的青壮年病例较多,占39.99%。职业分布主要是农民、散居儿童、学生、幼托儿童、民工、家务及待业。结论充分利用各种宣传媒体加强卫生防病知识宣教工作,切实履行公共卫生职责;在流行季节前深入重点场所(幼儿园、学校、企业),建立疾病防御体系;积极做好预防接种工作,实行入园、入校检验预防接种证制度,同时做好查漏补种工作,建立起有效的免疫屏障;疾控与相关部门加强合作与沟通,共同做好医院性感染的监测与防控,阻断梅毒、艾滋病经母婴传播。     

Common Exposure to STL Polyomavirus During Childhood

STL polyomavirus (STLPyV) was recently identified in human specimens. To determine seropositivity for STLPyV, we developed an ELISA and screened patient samples from 2 US cities (Denver, Colorado [500]; St. Louis, Missouri [419]). Overall seropositivity was 68%–70%. The age-stratified data suggest that STLPyV infection is widespread and commonly acquired during childhood.